July 2007


Yes, the title conjures up images of a futuristic world in which diabetics puff their way back to health. "New! Insulin Cigarettes!" In fact, it's rather more innocuous than that: scientists have engineered a type of insulin-containing tobacco plant that could - in theory, at least - be used as a diabetes treatment.

A study has just been completed of its use. Once freeze-dried and broken down into powder, the insulin-containing tobacco leaves were administered to mice. The scientists who came up with the plant (and who are based at the University of Central Florida), found the powder successfully prevented diabetes symptoms in the mice after eight weeks. It seems pretty safe to assume, they speculate, that humans with type 1 diabetes could get similar results from ingesting plant-based insulin.

The only snag so far is the image problem associated with tobacco. As a result, lead researcher Henry Daniell, is proposing a switch to lettuce, which is cheap, easy to grow and - oh, yeah! - is not associated with cancer. Good move.

The results of this study appear in the Plant Biotechnology Journal (July 2007).

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Ever wonder what would happen to a non-diabetic's blood sugar if they loaded up on a pile of concentrated sugar, preservatives and weird science fats? Doctors and the ADA call it prediabetes. This clip takes it to the extreme by sandwiching the center of 16 double stuff Oreos! Sometimes you have to be insanely blunt to make your point.

This is a brilliant example of the diabetes epidemic in action. In today's world -- many people are eating for convenience without realizing the consequences. More convenient equates to less nutritious - more preservatives, more sugar and even more fattening (the wrong fats, too!) The combination increases the amount of time our digestive enzymes need to work on these lab-derived ingredients. This sustains an elevated blood sugar following the time of consumption. Add the ADA definition of pre-diabetes (a blood sugar between 140 to 199 mg/dl 2 hours after a meal) and there you have it -- a potential player on Team Diabetes!

Think what would happen if this guy was in his doctor's office 2 hours after this stunt. I'd like to thank his employer for keeping him busy (whatever he's paid to do) well after the lunch hour - and protecting him from becoming another statistic. Big ups to HR for hiring this guy!! If he's not in marketing already -- you might consider a transfer and give this guy a raise. He's my Oreo hero.

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Chris just shared flip flops are not the wisest choice of footwear, especially for a diabetic. I love 'em at the pool, but nearly all other moments I sport shoes with plenty of support -- I only torture myself with heels on special occasions.

Check out this innovative product in the pipeline for the feet of people with diabetes. Zephyr Technology is developing a high tech inner sole to help detect and prevent foot ulcerations. Zephyr already makes smart fabrics capable of measuring skin temperature, heart beat, posture, activity and even breathing rates. They have recently teamed up with AUT University scientists to help develop its ShoePad product to measure temperature and pressure for early warning of problem areas. Zephyr says the ShoePad could prevent around 85 percent of the foot amputations performed on diabetics in the United States annually. Neuropathy and ischaemia are two main disorders underlying foot problems. If you don't feel an ulceration on the foot, it can become infected and possibly lead to amputation. Here is a clinical review of the diabetic foot, adapted from the ABC of Diabetes. Be prepared, there are some graphic pictures. But don't get freaked out, foot ulcerations are preventable and a majority are curable if treated promptly.

This new insole has fewer sensors than existing products, delivering an affordable, simple-to-use product. A marketable product will be awhile, the insole is still in research and development, but maybe you'll have the outside chance to slip a pair into your shoes during the clinical trials. I need a smart insole that tells me to "kick off those impractical high heels!" next time I'm on a wedding dance floor.

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Earlier today I blogged about the Avandia advisory panel which met today. As of earlier today, the word was an FDA official, David Graham, had issued a written preview of the comments he intended to make. In it, Graham stated his view that GlaxoSmithKline's diabetes drug Avandia is dangerous and should therefore be removed from sale.

Now comes breaking news from the Associated Press that the panel will recommend, against the wishes of many - Dr. Graham included, that Avandia stick around. According to the AP, government health advisers have argued that, hey, sure Avandia may cause increased risk of heart attack, but let's just keep it out there. What?! As of writing, the AP was still waiting for a tally of how the panel voted on the issue, but word is a majority voted against recommending a ban.

The FDA's patient representative for the panel was quoted as saying studies indicating Avandia causes heart trouble "have very significant weaknesses and are inadequate for us to make that kind of decision." In short, the FDA seems to be saying Avandia causes heart damage, but the study-based proof is not strong enough for a ban. Talk about your contradictory messages! Baffled? Disgusted? Join the club.

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What happens when you do "Supersize Me" in reverse? Why, you get a documentary like "Raw for 30 Days." The film-makers of "Raw" got six type 2 diabetics with less than stellar lifestyle habits and persuaded them to switch out hamburgers and fried chicken for a raw, whole foods diet consisting of all-organic, all-vegan foods. Mmm mmm.

You can't see the movie quite yet. But you can see the preview. Just click on over to the "Raw for 30 Days" website. My source says the preview can also be viewed on YouTube or Google Video. The finished product is now in post-production and should be released in time for Spring 2008 film festivals.

The documentary was directed by Sundance Film Festival-winner Aiyana Elliott, but the concept was created by the executive producer, Mark Perlmutter. The idea is to demonstrate that type 2 diabetes can be reversed "naturally" - that is, without the aid of a battery of prescription drugs. Says Perlmutter, "The release of our nine-minute preview may be the first exposure some have to a greater understanding of controlling, if not conquering the disease."

Okay, so the premise is a little shaky. For one thing: how much can be achieved in only thirty days? For another: it's changing lifestyle habits and maintaining them over time that's key in reversing symptoms of t2 diabetes or pre-diabetes. But why be a party-pooper? After all, raising awareness about diabetes is a good thing. I would definitely like to see this film.

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